Daniela Fassoni (2024)

1. Daniela Fassoni - Facebook

  • Daniela Fassoni · Studied at Sapienza Università di Roma · Lives in Latina, Italy · From Latina, Italy · Joined March 2019.

  • See posts, photos and more on Facebook.

2. Fassoni Maria Daniela - L'albar dai Fornes

  • Fassoni; Maria Daniela. Tree Photo/video gallery (3). Id: 12080. Gender: Female. Birth: 10/10/1968. Birth place: Udine. Occupation: Death: 13/08/2006.

3. Fassoni Maria Daniela - L'albar dai Fornes

4. Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a ...

  • 2 mei 2023 · View ORCID ProfileDaniela S. Santurio, Emanuelle A. Paixão, Luciana R.C. Barros, Regina C. Almeida, Artur C. Fassoni. doi: https://doi.org ...

  • Chimeric Antigen Receptor (CAR)-T cell therapy long-term follow-up studies revealed non-durable remissions in a significant number of patients. Some of the mechanisms underlying these relapses include poor CAR T cell cytotoxicity or persistence, as well as antigen loss or lineage switching in tumor cells. In order to investigate how antigen-mediated resistance mechanisms affect therapy outcomes, we develop a mathematical model based on a set of integral-partial differential equations. Using a continuous variable to describe the level of antigen expression of tumor cells, we recapitulated important cellular mechanisms across patients with different therapeutic responses. Fitted with clinical data, the model successfully captured the dynamics of tumor and CAR-T cells for several hematological cancers. Furthermore, the role played by these mechanisms are explored with regard to different biological scenarios, such as pre-existing or acquired mutations, providing a deeper understanding of key factors underlying resistance to CAR-T cell immunotherapy. Statement of significance Our study introduces the first mathematical model to characterize the influence of a continuous level of antigen expression on the interplay between Chimeric Antigen Receptor (CAR)-T cells and cancer cells. We examine various cellular mechanisms across different hematologic cancers, taking into account both antigen-positive and antigen-negative relapses. Our findings shed light on the role of antigen densit...

Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a ...

5. Daniela Klaiman - MIX PALESTRAS

  • Raphael Fassoni · Raphael Karan · Raphael Lassance · Raphael Martins · Raquel ... Daniela Klaiman é Futurista especialista em comportamento do consumidor, ...

  • Futurista. Formada em Tecnologia, Futurismo e Empreendedorismo pela Universidade Hebraica de Jerusalém e em Coolhunting & Trends pela Universidade Abat Oliba de Barcelona.

Daniela Klaiman - MIX PALESTRAS

6. Understanding the General Principles of T Cell Engagement by Multiscale ...

  • 7 jun 2023 · Daniela S. Santurio; Luciana R. C. Barros; Ingmar Glauche; Artur C. Fassoni. This article has no evaluationsLatest version Apr 27, 2024 ...

  • The use of bispecific antibodies as T cell engagers can bypass the normal TCR-MHC interaction, redirect the cytotoxic activity of T-cells, and lead to highly efficient tumor cell killing. However, this immunotherapy also causes significant on-target off-tumor toxicologic effects, especially when they were used to treat solid tumors. In order to avoid these adverse events, it is necessary to understand the fundamental mechanisms during the physical process of T cell engagement. We developed a multiscale computational framework to reach this goal. The framework combines simulations on the intercellular and multicellular levels. On the intercellular level, we simulated the spatial-temporal dynamics of three-body interactions among bispecific antibodies, CD3 and TAA. The derived number of intercellular bonds formed between CD3 and TAA were further transferred into the multicellular simulations as the input parameter of adhesive density between cells. Through the simulations under various molecular and cellular conditions, we were able to gain new insights of how to adopt the most appropriate strategy to maximize the drug efficacy and avoid the off-target effect. For instance, we discovered that the low antibody binding affinity resulted in the formation of large clusters at the cell-cell interface, which could be important to control the downstream signaling pathways. We also tested different molecular architectures of the bispecific antibody and suggested the existence of an opt...

Understanding the General Principles of T Cell Engagement by Multiscale ...

7. Daniela Grandón Silva - Universiteit Leiden

  • Bevat niet: fassoni | Resultaten tonen met:fassoni

  • Postdoc

Daniela Grandón Silva - Universiteit Leiden

8. [PDF] aluno_especial_2_21 (1).xlsx - DLCV/USP

  • Clara Fassoni Bonachela. ECLLP - FLC6445 - Produção de Sentido na ... Daniela da Silva Pereira. ECLLP - FLC6445 - Produção de Sentido na Leitura e ...

Daniela Fassoni (2024)

FAQs

What nationality is Daniela Washington? ›

Daniell "Danni" Washington is an American activist, artist, and presenter who campaigns for cleaner, plastic-free oceans. She founded the Big Blue & You, a non-profit organization.

What nationality is Daniela Darcourt? ›

Daniela Darcount is an international singer, dancer and actress from Peru. She has more than 3.1 million followers on Instagram, the salsa is her musical style. In 2022, she has already finished her Eurotour and is starting her USA Tour.

What country is Daniela from? ›

Variations. Dangela, Daniele, Kaniela

The name Daniela, originating from Spanish, holds a profound meaning that reflects the religious beliefs of its origin. Derived from the Hebrew name Daniel, Daniela signifies Only God is My Judge.

What ethnicity is Daniela Nieves? ›

Daniela Nieves is a Venezuelan-American actress best known for playing Andi Cruz on the Nickelodeon series Every Witch Way and WITS Academy.

What ethnicity is Daniela Melchior? ›

Daniela Melchior is a Portuguese actress and model who started in Portuguese-language films such as Parque Mayer and The Black Book.

What nationality is Silvio Rodriguez? ›

Cuban troubadour Silvio Rodríguez, 77, one of Latin America's most famous musicians, has released a new album, his first in three years.

What nationality is Daniela Romo? ›

Daniela Romo (born Teresa Presmanes Corona; 27 August 1959) is a Mexican singer, actress and TV hostess. During her career, she has sold 15 million records, making her one of the best-selling Latin music artists.

What nationality is Maddie White? ›

The English-born, Los Angeles native started on TikTok posting elaborate sewing videos where she would create lavish gowns from scratch.

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