1. Daniela Fassoni - Facebook
Daniela Fassoni · Studied at Sapienza Università di Roma · Lives in Latina, Italy · From Latina, Italy · Joined March 2019.
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2. Fassoni Maria Daniela - L'albar dai Fornes
Fassoni; Maria Daniela. Tree Photo/video gallery (3). Id: 12080. Gender: Female. Birth: 10/10/1968. Birth place: Udine. Occupation: Death: 13/08/2006.
3. Fassoni Maria Daniela - L'albar dai Fornes
Fassoni; Maria Daniela. Albero Photo/video gallery (3). Id: 12080. sesso: Femmina. nascita: 10/10/1968. Luogo di nascita: Udine. Condizione: morte: 13/08/2006.
4. Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a ...
2 mei 2023 · View ORCID ProfileDaniela S. Santurio, Emanuelle A. Paixão, Luciana R.C. Barros, Regina C. Almeida, Artur C. Fassoni. doi: https://doi.org ...
Chimeric Antigen Receptor (CAR)-T cell therapy long-term follow-up studies revealed non-durable remissions in a significant number of patients. Some of the mechanisms underlying these relapses include poor CAR T cell cytotoxicity or persistence, as well as antigen loss or lineage switching in tumor cells. In order to investigate how antigen-mediated resistance mechanisms affect therapy outcomes, we develop a mathematical model based on a set of integral-partial differential equations. Using a continuous variable to describe the level of antigen expression of tumor cells, we recapitulated important cellular mechanisms across patients with different therapeutic responses. Fitted with clinical data, the model successfully captured the dynamics of tumor and CAR-T cells for several hematological cancers. Furthermore, the role played by these mechanisms are explored with regard to different biological scenarios, such as pre-existing or acquired mutations, providing a deeper understanding of key factors underlying resistance to CAR-T cell immunotherapy. Statement of significance Our study introduces the first mathematical model to characterize the influence of a continuous level of antigen expression on the interplay between Chimeric Antigen Receptor (CAR)-T cells and cancer cells. We examine various cellular mechanisms across different hematologic cancers, taking into account both antigen-positive and antigen-negative relapses. Our findings shed light on the role of antigen densit...
5. Daniela Klaiman - MIX PALESTRAS
Raphael Fassoni · Raphael Karan · Raphael Lassance · Raphael Martins · Raquel ... Daniela Klaiman é Futurista especialista em comportamento do consumidor, ...
Futurista. Formada em Tecnologia, Futurismo e Empreendedorismo pela Universidade Hebraica de Jerusalém e em Coolhunting & Trends pela Universidade Abat Oliba de Barcelona.
6. Understanding the General Principles of T Cell Engagement by Multiscale ...
7 jun 2023 · Daniela S. Santurio; Luciana R. C. Barros; Ingmar Glauche; Artur C. Fassoni. This article has no evaluationsLatest version Apr 27, 2024 ...
The use of bispecific antibodies as T cell engagers can bypass the normal TCR-MHC interaction, redirect the cytotoxic activity of T-cells, and lead to highly efficient tumor cell killing. However, this immunotherapy also causes significant on-target off-tumor toxicologic effects, especially when they were used to treat solid tumors. In order to avoid these adverse events, it is necessary to understand the fundamental mechanisms during the physical process of T cell engagement. We developed a multiscale computational framework to reach this goal. The framework combines simulations on the intercellular and multicellular levels. On the intercellular level, we simulated the spatial-temporal dynamics of three-body interactions among bispecific antibodies, CD3 and TAA. The derived number of intercellular bonds formed between CD3 and TAA were further transferred into the multicellular simulations as the input parameter of adhesive density between cells. Through the simulations under various molecular and cellular conditions, we were able to gain new insights of how to adopt the most appropriate strategy to maximize the drug efficacy and avoid the off-target effect. For instance, we discovered that the low antibody binding affinity resulted in the formation of large clusters at the cell-cell interface, which could be important to control the downstream signaling pathways. We also tested different molecular architectures of the bispecific antibody and suggested the existence of an opt...
7. Daniela Grandón Silva - Universiteit Leiden
Bevat niet: fassoni | Resultaten tonen met:fassoni
Postdoc
8. [PDF] aluno_especial_2_21 (1).xlsx - DLCV/USP
Clara Fassoni Bonachela. ECLLP - FLC6445 - Produção de Sentido na ... Daniela da Silva Pereira. ECLLP - FLC6445 - Produção de Sentido na Leitura e ...
